One of the most common reasons for a rejection is that the agency doesn’t represent the subject or genre of the book. If the agency doesn’t represent what you’ve got to sell, then it’s a guaranteed rejection.
Agencies state on their website what they represent, so make sure you check the their submissions guidelines. Sometimes they also specify what they don’t represent as well. Some agencies give a broad statement that applies to the entire agency. Often, however, the individual agents will represent different subjects and genres. You may need to check each agent’s individual page on the agency’s website.
Suzanne Hartmann - 2010